Red Blood Cells If transfusing Red Blood Cells one of the following should be present: Hgb ≤ 7 g/dl / Hct < 21% Hgb ≤ 8 g/dl / Hct < 24% in post-operative surgical patients or cardiac or cerebrovascular disease Rapid or ongoing blood loss Patient with anemia and evidence to support the need for increased oxygen carrying capacity (e.g. chest pain, tachycardia or orthostatic hypotensionunresponsive to fluid resuscitation, or congestive heart failure) Perioperative Hgb<9 g/dl / Hct<27% and operative procedure or clinical situation associated with major, predictable blood loss Outpatients chronically transfused Anemia and acute coronary syndrome Platelets If transfusing Platelets one of the following should be present (Apheresis, Leukoreduced): Note: A single unit of apheresis platelets will usually increase the platelet count by 25-35,000/ Platelet count ≤10,000/μL: prophylactic in a patient with failure of platelet production Platelets <15-20,000/μL in patients with hematologic malignancy or on active chemotherapy Platelet count ≤50,000/μL: with active bleeding on an invasive procedure (either recent, in-progress or planned) Platelet count ≤100,000/μL: undergoing a neurosurgical procedure or with intracranial or ocular hemorrhage Platelet dysfunction (inherited or acquired) Class IV shock/low platelet count secondary to massive transfusion (consider concurrent FFP transfusion) Fresh Frozen Plasma If transfusing Fresh Frozen Plasma one of the following should be present: Note: Dose depends on the clinical situation and underlying disease process. When given for coagulation factor replacement a dose of 10-20 mL/kg is usually adequate; avg 3-6 units of FFP. Preoperative or bleeding pt with INR > 1.5 or significantly elevated PTT Emergent reversal of warfarin anticoagulation Active DIC Massive transfusion or large volume crystalloid infusion (for or to prevent dilutional coagulopathy) Other Cryoprecipitate If transfusing Cryoprecipitate one of the following should be present: Note: Pooled into bags of 5 units Fibrinogen ≤150 mg/dL + hemorrhage Fibrinogen < 80-100 mg/dl Dysfibrinogenemia Active DIC Uremic platelet dysfunction Massive transfusion Other Downloadable Blood Transfusion Guidelines